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Lack of biomarkers handicaps decision making in era of expanding treatment options

No improvement in survival or impact on recurrence, but pending studies leave door ajar

Study was stopped early due to enrollment issues, but lessons can still be learned

Significant improvement in 5-year distant relapse-free interval with higher risk score

Radiotherapy also resulted in fewer treatment-related adverse events

Nearly identical 5-year outcomes with no surgery, sentinel lymph node biopsy

Study results are "historic," expert says

Lower rates of mortality and cancer recurrence with mastectomy, salpingo-oophorectomy

No invasive cancer increase at 2 years, but editorialists say data don't back active monitoring

However, imlunestrant failed to improve PFS among entire trial population

Overall cancer detection rate was about 43% higher versus women who chose not to participate

Prevention and screening efforts accounted for 80% of those averted deaths

Nearly half of women with unusual or nonreportable cfDNA-sequencing results had cancer

Benefit shown in trial of patients flagged for high risk of cardiotoxicity