A study of human brain organoids suggested a complex relationship between and tau, suggesting that tau phosphorylation may act as an innate immune response in Alzheimer's disease. (Cell Reports)
Topline results from a HEALEY platform trial showed that fosigotifator, an investigational eIF2B activator developed by the longevity company Calico Life Sciences in collaboration with AbbVie, in amyotrophic lateral sclerosis (ALS).
Another HEALEY trial -- this one testing the eIF2B agonist DNL343 -- also in ALS, Denali Therapeutics said.
Linked Medicaid and Medicare records suggested an in people with autism spectrum disorder. (JAMA Network Open)
Researchers identified a molecular mechanism that underlies some . (Nature)
Anti-calcitonin gene-related peptide monoclonal antibodies for migraine prevention did not raise compared with onabotulinumtoxinA (Botox), according to Medicare data. (JAMA Neurology)
In naturally , the brain appeared to process new and old memories in separate phases. (Nature)
In humans, functional were linked with a behavioral deficit in the ability to downregulate unwanted memories. (PNAS)
Extended courses of nirmatrelvir/ritonavir (Paxlovid) had meaningful benefits for , a small case series suggested. (Communications Medicine)
Childhood was tied to late-life cognition in Black adults. (JAMA Network Open)
Here's what for people with Alzheimer's and dementia. (The Atlantic)