Don't Try ARBs for Severe COVID, Trial Indicates Harms seen without any compensating survival benefit Jul 12, 2024
Extended-Infusion Antibiotics Tied to Reduced Mortality From Bloodstream Infections Benefit limited to patients with severe illness or elevated minimum inhibitory concentrations Jul 04, 2024
Delirium During COVID Hospitalization Raises Disability, Cognitive Risks At-risk older adults should be screened, referred early for rehabilitation, researcher urges Jul 02, 2024
In-Hospital Continuous Glucose Monitoring Can't Budge T2D Control Randomized trial failed to get anywhere near tight glucose control Jun 25, 2024
SGLT2 Inhibitor No Help for ICU Patients With Acute Organ Dysfunction Secondary findings of trial only suggest a potential benefit in kidney protection Jun 14, 2024
PPI Prevents Upper GI Bleeds During Intubation, With No Effect on Mortality But expert still suggests the approach may not be appropriate for the most severely ill Jun 14, 2024
Acetaminophen Fails to Improve Mortality, Need for Organ Support in Sepsis However, treated patients were less likely to develop ARDS, respiratory dysfunction May 20, 2024
More Newborns Intubated on First Try With Video Laryngoscopy "Unusually high degree" of successful first attempts in trial, researchers say May 06, 2024
No Best Nutrition Strategy for Most Preemies Waiting to Breastfeed Trial in moderate to late preterm infants comparing a variety of common methods finds no winner Apr 24, 2024
AI Sepsis Diagnostic Tool Gets FDA Authorization EHR-embedded software algorithm uses biomarkers, clinical data Apr 03, 2024
Mobilizing ICU Patients May Not Affect Risk of Adverse Events, Death Implementing mobilization tied to a less than 3% risk of adverse events in meta-analysis Mar 21, 2024
Weight-Based High-Flow Oxygen for Bronchiolitis May Reduce ICU Admissions A weight-based high-flow nasal cannula protocol tied to 6.1% decrease per year in ICU admission Mar 19, 2024
Algorithm May Help Determine Oxygen Targets for Mechanically Ventilated Adults If results are "true and generalizable, then the consequences are staggering," editorialist says Mar 19, 2024
Staph Infections Appear to Be More Deadly for Women Understanding reasons behind mortality gap is "of critical importance," study author says Feb 27, 2024
Study Backs Recommended Antibiotic Approach for Aspiration Pneumonia Evidence of more side effects, lack of survival benefit with extended anaerobic coverage Feb 21, 2024
Midline Catheters Go Head-to-Head With PICCs for Bloodstream Infections For dwell times of 15 days or less, midline catheters noninferior, single-center study finds Feb 13, 2024
FDA Advisory Panel Generally Pleased With Pulse Oximetry Clinical Trial Proposal But some questions arose regarding number of participants, permissible variance in measurements Feb 03, 2024
Donor Milk, Formula Go Head-to-Head for Extreme Preemies in the NICU Similar neurodevelopmental outcomes, but less necrotizing enterocolitis with donor milk Jan 31, 2024
Critical Care Guideline Changes Boost Corticosteroid Uses, Role of Families Corticosteroids, glycemic control, and clinical deterioration outside ICU addressed Jan 25, 2024
Ibuprofen Fails Another Crack at Reducing Preemie Lung Issues and Deaths A therapy to help babies with hole in heart is still lacking Jan 24, 2024
Can Targeting Normoxemia Benefit Critically Ill Trauma Patients? Strategy appeared to increase supplemental oxygen-free days Jan 24, 2024
Tailoring Drug Interaction Alerts to the ICU Reduced Number of High-Risk Combos Intervention reduced "alert fatigue" for clinicians Jan 23, 2024
Ceftriaxone Prevents Ventilator-Associated Pneumonia After Brain Injury Single-dose administered prophylactically associated with less pneumonia, mortality Jan 22, 2024
Diagnostic Errors Common in Hospital Deaths, ICU Transfers, Study Suggests Mistakes were driven by patient assessment, testing, and often led to harm or death Jan 08, 2024
Inpatient COVID-19 Costs Substantially Outpaced Medical Inflation Hospital costs to treat COVID-19 estimated at a staggering $70 billion Jan 03, 2024
Giving Oropharyngeal Surfactant at Birth Is No Help to Preemies Increased rates of pneumothorax emerged among newborns treated prophylactically Dec 11, 2023
Conservative Oxygenation Outperforms Liberal Targets for Critically Ill Kids Oxy-PICU is the first randomized trial to compare different SpO2 targets in these patients Dec 05, 2023
Prone Positioning Falls Flat for Weaning COVID Patients Off ECMO Similar ECMO duration, mortality compared with supine position in randomized trial Dec 01, 2023
Safer to Hold Off on Intubating Comatose, Intoxicated Patients, Trial Finds French centers showed faster discharge, fewer adverse events Nov 29, 2023
Vitamin C Flops for Severe COVID-19 Trial data suggest chance of harm significantly greater than small possibility of efficacy Oct 25, 2023
Cryoprecipitate, REBOA Flop for Improving Major Hemorrhage Outcomes The first randomized trials of both approaches failed Oct 13, 2023
ECMO Has Become a Harder Sell in Severe COVID-19 Studies show decreased use, cast doubt on clinical benefit Oct 13, 2023
'Surprising' Contribution of Pulmonary Hypertension to ARDS Outcomes Coexisting conditions spell markedly poor clinical course Oct 12, 2023
Overdoing Blood Transfusions? JAMA Special Issue Shines a Light Also includes two negative trials in hemorrhage control Oct 12, 2023
Low Tidal Volume Compliance Still Lacking in Mechanical Ventilation Women, shorter patients, those with a high BMI more likely to receive higher tidal volumes Sep 29, 2023
No Benefit to Tight Glucose Control in ICU Trial attempts to settle the controversy once and for all Sep 29, 2023
Madonna's ICU Stay May Have Been Due to Sepsis Despite being life-threatening, sepsis can be easy to miss Jun 30, 2023
Sepsis Outcomes No Different With Prolonged Beta-Lactam Antibiotic Death and drug resistance unchanged no matter the duration of treatment Jun 20, 2023
Breathing Support Type Matters for Preventing Extubation Failure in the PICU CPAP, BiPAP, nasal cannula compared with conventional oxygen therapy Jun 05, 2023
Helmet CPAP Leads Noninvasive Ventilation Therapies for Acute Respiratory Failure Showdown of HFNC and helmet- and face mask-based modalities in meta-analysis Apr 23, 2023
